Multiple Updates in MySQL

I know that you can insert multiple rows at once, is there a way to update multiple rows at once (as in, in one query) in MySQL?
Edit: For example I have the following
Name   id  Col1  Col2
Row1   1    6     1
Row2   2    2     3
Row3   3    9     5
Row4   4    16    8
I want to combine all the following Updates into one query
UPDATE table SET Col1 = 1 WHERE id = 1;
UPDATE table SET Col1 = 2 WHERE id = 2;
UPDATE table SET Col2 = 3 WHERE id = 3;
UPDATE table SET Col1 = 10 WHERE id = 4;
UPDATE table SET Col2 = 12 WHERE id = 4;

Answer :

Yes, that's possible - you can use INSERT ... ON DUPLICATE KEY UPDATE.
Using your example:
INSERT INTO table (id,Col1,Col2) VALUES (1,1,1),(2,2,3),(3,9,3),(4,10,12)
ON DUPLICATE KEY UPDATE Col1=VALUES(Col1),Col2=VALUES(Col2);



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