Simplest way to profile a PHP script

What's the easiest way to profile a PHP script?
I'd love tacking something on that shows me a dump of all function calls and how long they took but I'm also OK with putting something around specific functions.
I tried experimenting with the microtime function:
$then = microtime();
myFunc();
$now = microtime();

echo sprintf("Elapsed:  %f", $now-$then);
but that sometimes gives me negative results. Plus it's a lot of trouble to sprinkle that all over my code.

==Answer : 
The PECL APD extension is used as follows:
<?php
apd_set_pprof_trace();

//rest of the script
?>
After, parse the generated file using pprofp.
Example output:
Trace for /home/dan/testapd.php
Total Elapsed Time = 0.00
Total System Time  = 0.00
Total User Time    = 0.00


Real         User        System             secs/    cumm
%Time (excl/cumm)  (excl/cumm)  (excl/cumm) Calls    call    s/call  Memory Usage Name
--------------------------------------------------------------------------------------
100.0 0.00 0.00  0.00 0.00  0.00 0.00     1  0.0000   0.0009            0 main
56.9 0.00 0.00  0.00 0.00  0.00 0.00     1  0.0005   0.0005            0 apd_set_pprof_trace
28.0 0.00 0.00  0.00 0.00  0.00 0.00    10  0.0000   0.0000            0 preg_replace
14.3 0.00 0.00  0.00 0.00  0.00 0.00    10  0.0000   0.0000            0 str_replace